MedChemExpress - Model Ned 19 -874374-25-1
Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM[1]. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice[2].MCE products for research use only. We do not sell to patients.
Ned 19
MCE China：Ned 19
Brand：MedChemExpress (MCE)
Cat. No.HY-103316A
CAS：874374-25-1
Purity：99.92%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
In Vitro：Ned 19 (25-100 μM; 24-72?hours) reduces cell proliferation[2]. Ned 19 (25-100 μM; 24-72?hours) reduces markedly the cell number[2]. Ned 19 (25-100 μM; 24-72?hours) reduces the S phase percentage and increases of the G0/G1 phase percentage evaluated by cell cycle analysis[2]. Ned 19 (25-100 μM; 24-72?hours) induces cell apoptosis a time-dependent manner[2]. Ned 19 (25-100 μM; 24-72?hours) reduces expression of N-cadherin and increases expression of E-cadherin, affecting the cell migratory behavior[2].
In Vivo：Ned 19 (i.p.; 5?mg/Kg/every second day; 4 week) impaires severely tumor growth[2].
IC50 & Target：NAADP, Ca2+[1] In Vitro Ned 19 (25-100 μM; 24-72?hours) reduces cell proliferation[2]. Ned 19 (25-100 μM; 24-72?hours) reduces markedly the cell number[2]. Ned 19 (25-100 μM; 24-72?hours) reduces the S phase percentage and increases of the G0/G1 phase percentage evaluated by cell cycle analysis[2]. Ned 19 (25-100 μM; 24-72?hours) induces cell apoptosis a time-dependent manner[2]. Ned 19 (25-100 μM; 24-72?hours) reduces expression of N-cadherin and increases expression of E-cadherin, affecting the cell migratory behavior[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ned 19 Related Antibodies Cell Proliferation Assay[2] Cell Line: B16 cells
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References：
[1]. Rosen D, et al. Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonistNed-19 indicate two binding sites on the NAADP receptor. J Biol Chem. 2009 Dec 11;284(50):34930-4. [Content Brief]
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