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Permethrin

MCE China：Permethrin

Brand：MedChemExpress (MCE)

Cat. No.HY-B0887

CAS：52645-53-1

Synonyms：NRDC-143

Purity：98.0%

Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes).

In Vitro：Permethrin (25 μM, 1 h) dose-dependently decreases the activity of total ATPase and the activity of Na+, K+-ATPase in vitro[5].

In Vivo：Permethrin (50, 500 and 5000 μg/kg BW, Dietary intake, daily for 12 weeks) promotes weight gain, total adipose tissue weight and aggravates high fat dietinduced insulin resistance along with high fat diet, but significantly decreases pAMPKα and pAMPKα/AMPKα expression in mouse[1]. Permethrin (0.1, 1, 10 µg/L, aqueous solution, 14 days) has higher relative expression of choriogenin (Chg) than the 1 ng/L Ethinylestradiol (EE2) (HY-B0216) treatment, and lower relative expression than the 10 ng/L EE2 treatment in Juvenile Menidia beryllina[6]. Permethrin (500 and 1000 mg/kg, diet mixed, daily for 14 days) has memory and spatial exploration dwindling effect, but no effects on anxiety and locomotion in rats [7].

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References：

[1]. Xiao X, et al. Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice. Food Chem Toxicol. 2018 Jan;111:405-416.  [Content Brief]

[2]. Smith LB, et al. CYP-mediated permethrin resistance in Aedes aegypti and evidence for trans-regulation. PLoS Negl Trop Dis. 2018 Nov 19;12(11):e0006933.  [Content Brief]

[3]. Shelley LK, et al. Immunotoxic and cytotoxic effects of atrazine, permethrin and piperonyl butoxide to rainbow trout following in vitro exposure[J]. Fish Shellfish Immunol. 2012 Aug;33(2):455-8.  [Content Brief]

[4]. Gassner B, et al. The pyrethroids permethrin and cyhalothrin are potent inhibitors of the mitochondrial complex I[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 281(2): 855-860.  [Content Brief]

[5]. Kakko I, et al. The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin and cypermethrin[J]. Chemosphere. 2003 May;51(6):475-80.  [Content Brief]

[6]. Brander SM, et al. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem. 2012 Dec;31(12):2848-55.  [Content Brief]

[7]. Omotoso G, et al. Permethrin exposure affects neurobehavior and cellular characterization in rats' brain. Environ Anal Health Toxicol. 2020 Dec;35(4):e2020022-0.  [Content Brief]