MedChemExpress - Model RCGD423 -108237-91-8
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.MCE products for research use only. We do not sell to patients.
RCGD423
MCE China：RCGD423
Brand：MedChemExpress (MCE)
Cat. No.HY-114775
CAS：108237-91-8
Purity：99.92%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
In Vitro：RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair[1].
In Vivo：RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage[1].
IC50 & Target：IL6-beta
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References：
[1]. Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769. [Content Brief]
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