MedChemExpress - Model SRI-37330 hydrochloride -2322245-49-6
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research[1].MCE products for research use only. We do not sell to patients.
SRI-37330 hydrochloride
MCE China：SRI-37330 hydrochloride
Brand：MedChemExpress (MCE)
Cat. No.HY-141623
CAS：2322245-49-6
Purity：99.72%
Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research.
In Vitro：SRI-37330 (1 μM, 24 h) hydrochloride inhibits the activity of the human TXNIP promoter in INS-1 cells[1]. SRI-37330 (1 μM, 24 h) hydrochloride inhibits Mrna and protein levels of TXNIP in INS-1 cells[1]. SRI-37330 (5 μM, 24 h) hydrochloride inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter[1]. SRI-37330 (5 μM, 24 h) hydrochloride lowers glucagon secretion in TC1-6 cells[1]. SRI-37330 (0-5 μM, 24 h) hydrochloride inhibits glucagon-induced glucose output from primary hepatocytes[1].
In Vivo：SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride decreases glucagon secretion and action and blocks hepatic glucose output[1]. SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride is well tolerated in male C57BL/6J mice[1]. SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice[1].
IC50 & Target：TXNIP[1] In Vitro SRI-37330 (1 μM, 24 h) hydrochloride inhibits the activity of the human TXNIP promoter in INS-1 cells[1]. SRI-37330 (1 μM, 24 h) hydrochloride inhibits Mrna and protein levels of TXNIP in INS-1 cells[1]. SRI-37330 (5 μM, 24 h) hydrochloride inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter[1]. SRI-37330 (5 μM, 24 h) hydrochloride lowers glucagon secretion in TC1-6 cells[1]. SRI-37330 (0-5 μM, 24 h) hydrochloride inhibits glucagon-induced glucose output from primary hepatocytes[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SRI-37330 hydrochloride Related Antibodies
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References：
[1]. Thielen LA, et al. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Sep 1;32(3):353-365.e8. [Content Brief]
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