Gentronix - Microflow (Flow MNT)
High throughput; Clastogenic & Aneugenic detection; Quick, cost effective, high quality results.
Flow MNT – Conducted on a miniaturised format and using flow cytometry to score both micronuclei and cytotoxicity, the flow micronucleus assay provides a rapid prediction of the in vitro micronucleus test. The miniaturised format enables the study to be performed using far less test item than an OECD 487 study, and results in more responsive delivery timelines.
Test Cell Line: TK6
Metabolic activation: Typically, induced rat liver S9, other sources
available.
3 hours (+S9) and 24 hours (-S9)
Short +S9
Long –S9
2 arm study
Typical test item requirements: 20 mg (ICH S2(R1)) - 50 mg (OECD 487)
Study Duration: < 3 Weeks
Endpoint: Micronucleus Formation / Chromosomal Damage