Microfluidic Multi Cell Cultivation with Automatic Sample Handling
The Microfluidic Workstation (MW) is a benchtop robot with “flying” work deck. It is made to operate small transparent bio containments, e.g. SBS well format objects, microfluidic cartridges and others. It features two tool heads for optical inspection in both directions. The upper tool head operates all GeSiM made tools for liquid handling, Nanolitre pipetting and paste dispensing. Full 3d printing is given by the modular approach of GeSiM instruments. The recesses of the work decks accept carriers for arbitrary target formats.
The configuration above accommodates an array of Multi-Organ-Chips (MOCs) on the left tray. Each MOC hooks up to a separate control unit for media and temperature adjustment. The MOC design can be adapted to different applications. For more details on the MOCs please click the tab “Applications”. The MOCs resulted from a joint research project with Fraunhofer IWS, Dresden.
Hypoxia Assay
- Oxygen control directly on culture media
- External gas mixer
- Gas permeable membrane for in/output
Systemic toxicity testing
- Two parallel-connected cell culture chambers (3), reservoir (2)
- 3-point-peristaltic-pump (1), inlet and outlet valves (4)
- Temperature controlled support
The measurement cameras can be configured to different detection methods, e.g. fluorescence microscopy, phase contrast microscopy and turbidity measurement for ELISA.