Model COMU -Optimal Properties As A Peptide Coupling Reagent

Purity
≥98.0%

Molecular Formula
C12H19F6N4O4P

Molecular Weight
428.27 [gr/mol]

Appearance
White to off-white crystalline powder

Storage Conditions
Store in a cool and dry place (2-8oC)

• Epimerization during fragment coupling appears to be lessened with COMU® than with HOBt or HATU.
• COMU® is fully compatible with microwave-assisted peptide synthesis.
• COMU® is very soluble in most commonly employed peptide coupling solvents, such as DMF or NMP, which makes it ideally suited for solid-phase peptide synthesis.
• It is equally attractive for solution-phase synthesis since by-products formed by COMU® are water-soluble and can be separated by simple extraction.
• A color change during the reaction allows visual or colorimetric reaction monitoring.
• COMU® can be used with nearly identical protocols that apply for common coupling reagents such as HBTU, TBTU, PyBOP, or HATU.
• It is considered the greener coupling reagent.
• It is used in some Canadian schools.