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Model DNA/RNA Defend -Gold Standard Buffer
DNA/RNA Defend™ is the RUO and colorless version of InActiv Blue®, a guanidine-based medium for pathogen inactivation, stabilization of DNA and RNA, and lysis of biological samples. Requires nucleic acid extraction.
DNA/RNA Defend™ protects RNA when keeping biomaterials stored at room temperature, even for the most complex sample types such as whole blood and saliva.
Stability of SARS-CoV-2 viral particles stored in buffer at room temperature for up to 30 days
RT-qPCR results for SARS-CoV-2 E-gene in DNA/RNA Defend buffer spiked with low or high viral titer and stored in the fridge (4 °C) or at room temperature (RT) for 30 days (n=12).
Freeze-thaw stability (n=6)
Buffer with nasopharygeal swab samples inoculated with high and low viral titer were exposed to 5 freeze-thaw cycles, followed by RNA extraction and RT-qPCR
Stability of RNA in urine for up to 9 days at 37 °C
RT-qPCR results for KLK3 gene on RNA extracted from urine of 3 healthy donors spiked with LNCaP cells and stabilized with DNA/RNA Defend buffer.
Similar results for HOXC6 and DLX1 (not shown). Data courtesy of mdxhealth.