NETRI
Model DuaLink MEA -Microfluidic Chip
FromNETRI
With the DuaLink™ MEA microfluidic chip, the the microchannels, NeoBento™ and MEA compatibility technologies are combined in a single microfluidic chip, thus providing an unmatched user experience combined with double microfluidic isolation and neuronal functional analysis. Functional double fluidic isolation, Functional bilateral connectivity (one to one) by microchannels technology, Three compartments, crowded on a MicroElectrod Array (MEA) plate: two compartments for cell culture and one for fluidic isolation, 8 or 16 microfluidic chips per NeoBento™
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microfluidic chip
cell culture
microfluidic
well plate
microfluidic device
drug screening
liquid chromatography
assay
ELISA analysis
mass chromatography
- Human cells (apparently healthy, diseased, engineered...)
- Rodent cells
- Structural and functional analysis
- Electrophysiology
- Immufluorescence
- Live Dead Assays
- Live staining
- Liquid chromatography
- Mass Spectoscopy
- Lysis cells/supernatant analysis
- ELISA
- Synaptic compartimentalization (pre-, post- and synaptic compartments)
- Synaptic transmission and localization
- Axonal transport
- Mitochondrial transport
- Microglial cells migration
- Culture up to 3 different cell populations
- Neuroinflammation
- Huntington`s disorders (cortico-striatal)
- Study of the functional activity of neurons
- Analysis of the functional influence of a non-neuronal cell population on neurons
- Drug screening
- Quantitative assays
- Microchannels: Microchannels are rectangular slits engraved within microfluidic chips. Due to their micrometric measurements (3µm height, 5µm width), only cell extensions like neurites can grow within the microchannels, leaving the cell bodies within the compartments themselves. They allow also an enhanced fluidic isolation.
- NeoBento™: The NeoBento™ format makes NETRI’s microfluidic devices as versatile and easy to handle as a typical 96-well plate, by being in the standard AINSI format. The NeoBento™ is compatible with routine control magnification imaging (x10, x20,...) and confocal or high magnification (x63 with water immersion) imaging. Its versatility allows users to perform High Throughput Screening, histochemical analysis and individual cell fixation. Finally, its compounds permit an optimized oxygenation without expensive equipment (pump or stirrer) and a controlled humidity of cell culture.
- MEA Compatibility: The bounding of NETRI microfluidic chips on MEA plates allows functional analysis combine with structural analysis. DuaLink MEA allows to compare directly on the same chip the functional activity of 2 different neuronal types.