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Model DuaLink Shift -Microfluidic Chip

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With the DuaLink™ Shift microfluidic chip, the microchannels, and NeoBento™ technologies are combined in a single microfluidic chip, thus providing an unmatched user experience combined with physiological synaptic compartimentalization. Synapse isolation: Asymmetrical shape with microchannels of different length (shorter length between the first and second channel than between the second and third channel), Three compartments for cells co-culture connected by microchannels technology, 8 or 16 microfluidic chips per NeoBento™

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  • Human cells (apparently healthy, diseased, engineered...)
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  • Synaptic compartimentalization (pre-, post- and synaptic compartments)
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  • MicrochannelsMicrochannels are rectangular slits engraved within microfluidic chips, allowing a bilateral connectivity. Due to their micrometric measurements (3µm height, 5µm width), only cell extensions like neurites can grow within the microchannels, leaving the cell bodies within the compartments themselves. They also allow synaptic isolation.
  • NeoBento™: The NeoBento™ format makes NETRI’s microfluidic devices as versatile and easy to handle as a typical 96-well plate, by being in the standard AINSI format. The NeoBento™ is compatible with routine control magnification imaging (x10, x20,...) and confocal or high magnification (x63 with water immersion) imaging. Its versatility allows users to perform High Throughput Screeninghistochemical analysis and individual cell fixation. Finally, its compounds permit an optimized oxygenation without expensive equipment (pump or stirrer) and a controlled humidity of cell culture.