Model MF-TDP-0060 -TDP-43 IMR Reagent

TDP-43 is a neuronal protein that is implicated in the presence of neurodegenerative diseases. The “MagQu” TDP-43 IMR reagent is designed for quantifying TDP-43 protein by Immuno Magnetic Reduction (IMR). We conjugate antibody on the surface of around 50 nm-in-diameter Fe3O4 magnetic particles. When the antibodies on the surface bind with TDP-43 protein, the magnetic particles form clusters. Therefore, the ac susceptibility (Xac) of magnetic particles would be reduced in the applied ac magnetic field. By measuring the reduction of Xac, we can quantify TDP-43 protein in the sample easily and accurately.4,5