YMC Contichrom - Model LPLC -Multi-Functional, Twin-Column Chromatography
YMC Contichrom TWIN’s two-column configuration facilitates continuous chromatography from process development to large-scale biopharmaceutical production. This GMP-ready, easy-to-use chromatography system features a platform that offers a wide range of flow and column sizes and can be configured to operate in multiple modes.
The YMC Contichrom TWIN LPLC is an easy-touse, GMP-ready, multi-column chromatography system offering analytical performance for continuous, integrated or batch chromatography from process development to large-scale biopharmaceutical production. The Contichrom TWIN platform spans a wide range of flow and column sizes and has several options to incorporate multiple functionality on a single unit. The Contichrom TWIN is built on YMC ChromaCon’s CaptureSMB patented approach to twin-column purification. Because of the twocolumn configuration, the Contichrom TWIN is a simple design that facilitates continuous or semicontinuous chromatography implementation, reduces risk of costly downtime, and minimizes operating expenses. It is well suited for capture steps using Protein A or IEX separations for most protein purification processes.
This advanced system can be configured to operate in multiple modes: batch, integrated polish and continuous chromatography with enhanced buffer in-line dilution (BID). The design accommodates parallel or in-series column configurations for integrated polish using an onboard BID for in-line adjustment of pH, thus eliminating any hold up step.
A buffer, feed and CIP manifold that enables aseptic connection to single use bags is available and allows a closed environment to be maintained between runs.
- Faster processing by up to 3x
- Improved Protein A and buffer utilization by up to 50%
- Simple design to facilitate GMP validation
- Exclusive digital fluid management
- Ability to perform batch, integrated polish and continuous processes
- On-board buffer in-line dilution option
- Scale-up/-down from Contichrom®
CUBE bench-top instrument
- Space-saving, compact footprint
The flexible functionality of Contichrom TWIN, its precision performance and simple design, enables users to experience increased productivity and buy one unit that does the work of several systems, which translates into an increased ROI compared to other chromatography systems. The multi functionality of the system increases asset value allowing the use of the same skid for batch, integrated polish and continuous operations.