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OLS - Model xCELLigence -Live Cell Analysis System
Cell culture is a crucial step for all stages and applications of life science research. Whether you are creating a biobank, running diagnostics, studying complex immune-oncology of patients or running drug discovery processes, quality of cell culture has to be at its best. Improper handling, maintenance and most importantly monitoring of cell culture concentrations can lead to unhealthy cells that alter results and produce artifacts
Allowing cells to overgrow before an experiment can produce cells that are about to die or undergo apoptosis. Over a period of time, one might end up selecting cells that are more fit to handle harsh environmental conditions, with a migration and morphology profiles that are different from healthy cells at physiological conditions.
For basic cell culture, monitoring cells through the process of live cell analysis is an ideal way to go. Our Live Cell Analysis System xCELLigence, is your ideal cell culture partner for every step of the way. Using the xCELLigence Real-Time Cell Analyzer, you can monitor your cell numbers, cell-cell contacts, cell morphology over time as well as their migratory and invasive properties.
For virology research, virus-infected cells often display the cytopathic effect (CPE), reflecting morphological changes, cell fusion, lysis or the formation of inclusion bodies. Our Live Cell Analysis System xCELLigence allows detection of subtle changes occurring during CPE, like changes in cell-surface adhesion that can easily be missed by microscopy.
Indeed, the xCELLigence Real-Time Cell Analyzer allows you to study cells in co-culture as well. Secretory proteins such as cytokines and chemokines, can lead to induction or reduction of cell proliferation, altering in normal cell development and tumorigenesis. This can be helpful in studying immune-tumor interaction in immune-oncology as well.
Highlights - Live Cell Analysis System xCELLigence
- Continuously monitor live cell proliferation, morphology and viability
- No cell labeling required
- Impedance-based real-time analysis
- Different throughputs from 16 to 4×384 well formats
- Kinetic read-out – capture both short (sec) and long-term effects (days)
- Easy – Walk-away operation
- Exceeds limitations from endpoint-assays
Live cell analysis with xCELLigence®– much more than an endpoint assay can deliver.
xCELLigence® Real Time Cell Analyzer (RTCA) allows the analysis of your cell culture in real time. A huge variety of cell-based assays, such as proliferation, adhesion, cytotoxicity, migration, morphological changes and more can be performed (for detailed information please visit our download section). Furthermore, xCELLigence® is scalable. Depending on your throughput, evaluate 16 up to 4 x 384 well-plates simultaneously.
Highly Sensitive: The impedance-based technology is highly sensitive, allowing very low effector to target ratios. Continuous cell monitoring in real time enables investigation of short- and long-term effects. As a result, a full kinetic read out of the cellular behaviour is obtained- objective and quantitative.
Non-Invasive: xCELLigence® requires no cell labeling, which increases the physiological relevance and reduces the workload.
Easy to operate: Now run your cell-based assays with xCELLigence® RTCA easily. Literally! Click on RUN button and RELAX.
xCELLigence® RTCA technology allows detection of minimal cellular changes, involving strength of adhesion, cell number, cell morphology and cell-cell-contacts. All these properties influence cellular impedance signal that is continuously measured as Cell Index. Thus, xCELLigence RTCA provides deep insight into whole kinetics of cellular behaviour without any cell-labelling and with only minimal hands-on-time.