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SieversModel 500 RL -On-Line TOC Analyzer

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Reliable, accurate performance for online TOC monitoring and real-time testing. Used extensively in the pharmaceutical industry, the Sievers 500 RL On-Line TOC Analyzer offers unmatched stability and performance. It provides online TOC analysis for compliance with USPand other global pharmacopeia and can be provided with the critical protocols required for real-time testing (RTT) process validation. Specific features are offered for pharmaceutical applications, such as automated validation and system suitability testing, the ability to measure USPconductivity, and compliance with 21 CFR Part 11. The 500 RL uses the most robust analytical technology available and is easy to implement and maintain.

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Pharmaceutical Industry Compliance

The Sievers 500 RL is engineered to meet stringent global regulatory requirements in the pharmaceutical industry, including USP, EP 2.2.44 Total Organic Carbon, IP 2.4.30, CP Appendix VIII R, and JP16 2.59 monographs for Purified Water and Water for Injection. Sievers DataGuard software facilitates compliance with 21 CFR Part 11.

Accuracy. Efficiency. Integrity.

  • 150% faster analysis time
  • Advanced communications: Ethernet, WiFi, 4-20mA, Modbus, Profinet, and Serial connectivity
  • 10-inch color touchscreen
  • Super iOS 4-port sampler automates grad samples to improve productivity
  • Simultaneous TOC & conductivity measurement
  • Automated system suitability calibration, & validation
  • 50% faster validation protocols
  • IP55 & full IP connections
  • Same footprint as 500 RL for easy upgrades

Total Organic Carbon*

  • Linear Range 0.03 to 2,500 ppb as C
  • Precision < 1% RSD or 0.03 ppb as C, whichever is greater
  • Accuracy ± 5% of measurement
  • pH Range 5.5 to 8.0 in order to meet accuracy specification
  • Analysis Modes On-line, on-line averaged, on-line timed
  • Analysis Time Continuous mode: 6 minutes
  • Average and timed modes: 0.5, 1, 4, 8, or 24 hours
  • Ozone Compatibility** Maximum 200 ppb as O3
  • External Flow Rate Minimum 50 mL/min
  • Sample Temperature 1–95 °C (34–203 °F)
  • Sample Pressure Up to 100 psig
  • Interferences Insensitive to organic heteroatoms
  • Calibration Stability Typically 12 months
  • Display Readout 3 significant digits

Conductivity*

  • Raw Conductivity Range: 0.01 to 35 µS/cm
  • Conductivity Accuracy: ± 0.005 µS/cm or ± 1%, whichever is greater
  • Conductivity Precision: less than 1.0% RSD

Instrument*

  • Power Requirements: 100–240 VAC, 70 W, 50/60 Hz
  • Fuses: No user-replaceable fuses
  • Normal Operating Environment: Intended for indoor use only
  • Ambient Temperature: 5–40°C (41–104°F)
  • Maximum Relative Humidity: Up to 95%, noncondensing
  • Maximum Altitude: 3,000 m (9,843 ft)
  • Inputs: Two isolated binary inputs
  • Outputs: Serial (RS-232), one USB, three 40-20 mA, four alarms, one Ethernet
  • Installation/Overvoltage: II (protects against transients present in Category II power)
  • Safety Certifications: CE, ETL listed. Conforms to UL Std. 61010-1. Certified to CSA 22.2 No. 61010-1.
  • Pollution Degree: 2 (normally only non-conductive pollution)
  • Display: Backlit 10.1", 1280x800, touchscreen display
  • Size: H: 43.4 cm (17.1 in); W: 55.9 cm (22.0 in); D: 28.7 cm (11.3 in)
  • Weight: 16.3 kg (36 lb)
  • IP Rating: IP 55
  • Optional Wi-Fi: 802.11ac/a/b/g/n Dual-band 2.4/5 GHz
  • Industrial Communications Protocol: Modbus RCP/IP & Profinet (Included), Profibus (Optional)