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PharmigeneModel HLA-B*27 -RT-PCR & SYBR Green Based Detection Kit

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RT-PCR & SYBR Green based detection method: each sample requires only 2 PCR rxns for detecting of HLA-B*27 and Internal Control. Analysis is based on Ct values.

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  • Required only hours from blood sample to results.
  • Designed for easy operation & analysis.
  • High sensitivity of major HLA-B*27 subtypes which include HLA-B*2701 ~ 2707.
  • Mix & Match design.

The presence of HLA-B*27 allele is strongly associated with ankylosing spondylitis (AS), a chronic inflammatory disease of the axial musculoskeletal system and a few other rheumatic disorders (Reiter`s syndrome, acute anterior uveitis, and inflammatory bowel disease). HLA-B*27 testing is routinely used to screen for AS since ~90% of patients with AS have the HLA-B*27 allele. The geographical distribution of the different subtypes of HLA-B*27, with HLA-B*2705 being common in Caucasians and American Indians, HLA-B*2704 and 2706 in Asians and HLA-B*2702 in Mediterranean populations.