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PolareanModel 9800 -129Xe Hyperpolarizer

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The 9800 129Xe hyperpolarizer provides a routine supply of high-purity, hyperpolarized 129Xe for gas phase magnetic resonance studies. The polarizer is typically installed near the MRI/NMR suite and processes a custom mixture of unpolarized 129Xe, N2, and 4He, into one or more doses of pure hyperpolarized 129Xe that is available for magnetic resonance studies. There is no chemical change associated with hyperpolarization—only nuclear spin alignment and cryogenic extraction of pure xenon. The hyperpolarized 129Xe is then thawed and dispensed into a container or bag. Once dispensed into an appropriate container, and maintained within a modest holding magnetic field, the polarization relaxes with a T1 of 1-2 hr.

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System Overview and Specifications
The 9800 Xenon Hyperpolarization system can be operated on site by personnel who have undergone appropriate training. Polarization levels range from 7-15% depending on the volume of xenon processed. The system operates as a Class I laser, and thus requires no laser protective eyewear during normal operation.

System Components
  • Polarizer cart, compatible with either 3He or 129Xe cartridges
  • 129Xe hyperpolarization cartridge
  • 795nm optical pumping laser in Class I housing
  • Circular polarizing and beam collimating optics
  • Mass flow and pressure readings
  • High-field cryogenic accumulation area
  • Vacuum Pump/Purge to prepare delivery vessel
  • Flow-through optical cell containing Rb metal
  • Laser Transmission and Spectral Diagnostics
  • Aluminosilicate optical cell containing Rb metal
  • Laser Transmission and Spectral Diagnostics
  • Safety Interlocks
  • Power Distribution
Safety Features
  • Filtered power distribution
  • Air flow interlocks
  • Interlocked protective laser housing for Class I operation
  • CE Mark, UL and CSA approval
  • DOT approved shipping of replacement optical cells
Optional Equipment and Services
  • Polarization measurement station with absolute calibration for 3He and 129Xe
  • 129Xe cylinder manifold for connecting xenon mixture, UHP N2, and commercial N2 tanks
  • 3He hyperpolarization cartridge
  • Dose mixing syringes
  • Thermal QA phantoms
  • On-site installation and training
  • Training services at Polarean Imaging plc.
  • Regulatory affairs support
Polarizer Dimensions
  • 170cmL x 60cmW x 160cmH (65”L x 24”W x 60”H)
Laboratory Space Requirements
  • Controlled space capable of temporary Class IV laser operations
  • Minimum room dimensions:
    • width 120" (3m)
    • depth 84" (2m)
    • height 84" (2m)
  • Ferrous materials to be at least 3` (1m) away from the polarizer
  • Local ambient magnetic field preferably less than 1 Gauss
Electrical Requirements
  • 3 phase 208 V, 47-63 Hz, 20 A per phase
  • Power outlet: US NEMA L21-30R
  • Lockable isolate box
Compressed Air
  • 20 psig (1.5 bar) minimum pressure
  • 4 standard cubic feet per minute (110 L/min) minimal flow
  • 0.01% water maximal content
Environmental Requirements
  • 5 kW maximal power load
  • Room temperature between 68-75 ºF (20-24 ºC)
  • Dedicated temperature control
Supplies and Consumables
  • External 129Xe-4He-N2 tank
  • External UHP N2 tank
  • External commercial N2 tank
  • Liquid nitrogen
  • Dose delivery bags