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Polarean - Model 9820 -129Xe Hyperpolarizer
The 9820 129Xe hyperpolarizer provides a routine supply of high-purity, hyperpolarized 129Xe for gas phase magnetic resonance studies. The polarizer is typically installed near the MRI/NMR suite and processes a custom mixture of unpolarized 129Xe, N2, and 4He, into one or more doses of pure hyperpolarized 129Xe that is available for magnetic resonance studies. There is no chemical change associated with hyperpolarization-only nuclear spin alignment and cryogenic extraction of pure xenon. The hyperpolarized 129Xe is then thawed and dispensed into a container or bag. Once dispensed into an appropriate container, and maintained within a modest holding magnetic field, the polarization relaxes with a T1 of 1-2 hr.
The new generation 9820 xenon polarizer features a tunable 200W water-cooled narrowed linewidth laser, an expanded oven to accommodate substantially larger volume cells, and a 4-coil electromagnetic field configu-ration to provide uniform coverage over the oven and polarized gas plumbing.
The standard 9820 xenon polarizer configuration comes with a 1.5-L optical pumping cell, a triple-zone temperature control system, custom optics to deliver a highly uniform laser beam across the entire cell length, and a high efficiency cryogenic xenon collection system. The 9820 platform is designed with several expansion options to enhance performance and throughput as new components become available.
The 9820 Xenon Hyperpolarization system can be operated on site by personnel who have undergone appropriate training. Polarization levels range over 35-45% depending on the volume and throughput of produced xenon, typically at 1-3 L/h. The system operates as a Class 1 laser, and thus requires no laser protective eyewear during normal operation.
The 9820 Xenon Hyperpolarization system is designed for research use. If the system is used to produce hyperpolarized 129Xe for hu-man inhalation, all applicable institutional and federal approvals must be obtained.
- Custom hyperpolarized 129Xe compatible valves and tubing
- 129Xe hyperpolarization collection plumbing within the electromagnetic field
- Narrowed linewidth tunable 200W 795-nm optical pumping laser in Class 1 housing
- Circular polarizing and beam collimating optics
- Mass flow and pressure transducers
- Closed circuit water chiller for robust temperature control
- High-field high-capacity cryogenic ac-cumulation area
- Vacuum pump and purge function to prepare delivery containers
- Shielded oven with dual-action active heating/cooling temperature contro
- Flow-through optical cell installed in series with rubidium pre-saturator each with its own dedicated temperature control
- Laser transmission and spectral monitoring
- Safety Interlocks
- Central Power Distribution
- Filtered power distribution
- Air flow interlocks
- Interlocked protective laser housing for Class I operation
- CE Mark, UL and CSA approval
- DOT approved shipping of replacement optical cells
- Polarization measurement station with absolute calibration for 3He and 129Xe
- Dual source 129Xe cylinder manifold for real-time switching between natural abundance and enriched xenon mixes. This minimizes the risk of system contamination and downtime during frequent xenon cylinder changes.
- Heavy duty external purifier module with bypass function installed between the external gas manifold and the polarizer in order to further purify the gas mixes, protect the system against potential contamination and prolong the life of optical cells at their peak performance.
- Dose mixing syringes
- 170cmL x 60cmW x 160cmH (65”L x 24”W x 60”H)
- 3 phase 208 V, 47-63 Hz, 20 A per phase
- Power outlet: US NEMA L21-30R
- Lockable isolate box
- 20 psig (1.5 bar) minimum pressure
- 4 standard cubic feet per minute (110 L/min) minimal flow
- 0.01% water maximal content
- 5 kW maximal power load (17,000 BTUH = 1.5 Ton)
- Room temperature between 68-75 ºF (20-24 ºC)
- Dedicated temperature control
- External 129Xe-4He-N2 tank
- External UHP N2 tank
- External commercial N2 tank
- Liquid nitrogen
- Dose delivery bags