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MedChemExpressModel Pimethixene maleate -13187-06-9

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Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].
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Pimethixene maleate

MCE China:Pimethixene maleate

Brand:MedChemExpress (MCE)

Cat. No.HY-B1101A

CAS:13187-06-9

Synonyms:Pimetixene maleate

Purity:99.94%

Storage:4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.

IC50 & Target:5-HT2B Receptor 10.44 (pKi) 5-HT2A Receptor 10.22 (pKi) 5-HT2C Receptor 8.42 (pKi) 5-HT1A Receptor 7.63 (pKi) M2 receptor 9.38 (pKi) M1 receptor 8.61 (pKi) D2 receptor 8.19 (pKi) DD4.4 receptor 7.54 (pKi)

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References:

[1]. Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.  [Content Brief]

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