Prochrom - Model LP 300, 600, 1400 mm (Internal Diameter) -Bio Columns
Our low-pressure chromatography columns are designed for convenience and high-performance: Robustness: Prochrom®-Bio columns are recognized for their durability and reliability. We guarantee the performance and robustness of both our systems and processes. Performance: The flow distribution has been optimized with more than 25 years’ experience designing industrial chromatography equipment to reach the best chromatographic efficiencies with any media, maximizing the purity and recovery yield of your biopharmaceutical. Flexibility: Hydraulically actuated piston provides the user with unparalleled flexibility during preparatory, manufacturing, cleaning and maintenance operations. The piston height can be adjusted independently in a few seconds by a single operator! Adaptability: Guaranteed high performance with all media and column heights.
Because chromatography is an important and ubiquitous unit operation in downstream bioprocessing, FDA inspectors are showing an increased interest in the reproducible packing characteristics of chromatography columns. Novasep provides two efficient packing systems, depending on the size of the column.
- Elemental Packing (150 – 300 mm)
For pilot-scale columns (150 – 300 mm), Elemental packing reduces the tasks and the number of units to their strict minimum without compromising packing performance.
- Easy to use: No need to carry the piston or to pour the slurry so it can be easily manipulated by anyone. It shows excellent results achievable in a few minutes on the first attempt.
- Reproducible results: Thanks to a limited number of steps, results are not dependent on the skills of the operator so they are highly reproducible.
- No extra devices: The column is self-sufficient and does not require any extra devices such as pumps or packing units, limiting the investment required.
- Automated Packing (450 – 1600 mm)
Prochrom®-Bio Automated packing units bring true advantages to the user by optimizing media slurry injection and minimizing time outside of manufacturing steps. Combining the packing unit with Prochrom®-Bio column from 450 to 1600 mm provides the following benefits during packing, repacking in place and unpacking operations:
- Homogeneous packing, right the first time: The packing is performed in upflow mode from the packing valves located on the bottom of the column, preventing settlement effect and ensuring better packing performance. A repack in-place in situ procedure is available and may prevent from unpacking and repacking the column.
- A single and unique packing method: No need to screen multiple parameters.
- Simplified maintenance: Column maintenance is performed at ground level and the number of spare parts is limited.
- No media waste: Inject the exact required volume of resin into the column without any additional margin and save up to 5 –10% slurry.
- Reproducible packing guaranteed with batch record: Once the packing conditions have been defined, they are saved as a recipe and can be repeated automatically. The packing quality becomes operator-independent and reproducible.
- Quick unpacking: The unpacking operation is performed quickly and with very little buffer (2 to 3 CVs) thanks to the motorized piston which continuously reduces the remaining volume to be flushed. The recovered gel can be reused immediately with no further retreatment.
