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ALL Chemistry Inc. - Model SJAK10571 - ...

ALL Chemistry Inc. - Model SJAK10571 -Pyridone 6

Pyridone 6 is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.