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Q Exactive BioPharma - LC-MS Mass Spectrometers Platform
Realize complete BioPharma characterization with the Thermo Scientific Q Exactive BioPharma platform, which offers distinct operational modes optimized for the top three protein characterization workflows: High Mass Range mode offers optimized intact protein analysis under both native and denaturing conditions providing the highest quality spectra. Protein mode ensures isotopic resolution of subunits and and facilitates top/middle-down sequencing. Standard mode performs peptide mapping with unparalleled acquisition speed, mass accuracy, and spectral quality.
The Thermo Scientific™ Q Exactive™ Plus, Q Exactive HF and Q Exactive HF-X Hybrid Quadrupole-Orbitrap™ mass spectrometers add superior denatured and native MS intact analysis and subunit top/middle-down analysis capabilities to the most powerful benchtop peptide mapping instruments available. When combined with Thermo Scientific™ BioPharma Finder™ software it provides a complete integrated hardware and software solution for BioPharma characterization.
The Thermo Scientific™ Q Exactive™ BioPharma platform offers distinct operational modes that have been optimized for the top 3 protein characterization workflows:
- High Mass Range (HMR) mode was designed specifically for intact therapeutic protein workflows with the aim of providing ease of use an flexibility as needed. HMR mode is optimized for both conventional intact monoclonal antibody analysis performed in denaturing conditions, as well as native MS analysis which is ideal for antibody drug conjugates (ADCs) and other heterogeneous antibody samples.
- Protein mode on the Q Exactive HF is a powerful combination that has set the standard for the highest quality isotopically resolved data achievable on a benchtop mass spectrometer. Deconvolution of subunit MS spectra is easy and powerful with Thermo Scientific™ BioPharma Finder™ Software.
- Peptide mapping with Standard mode is state-of-the-art with the Q Exactive BioPharma, which is a culmination of decades of leadership in the development of data dependent acquisition (DDA).
Take discovery and sample analysis to the next level with our innovative cloud solutions
MS Instrument Connect allows you to:
- Schedule your equipment and monitor experiments
- Monitor real-time instrument status
- Track system utilization and historical events
- Stay informed when runs complete or system errors occur through email
- Mass Range: 50 to 8,000 m/z
- Scan Rates: Up to 18 Hz
- Dynamic Range: >5,000:1
- Mass Accuracy: Internal: <1 ppm RMS; External: <3ppm RMS under defined conditions
- Polarity Switching: One full cycle in <1 sec (one full positive mode scan and one full negative mode scan at a resolution setting of 35,000)
- Sensitivity: Full MS: 500 fg buspirone on column S/N 100:1
- SIM: 30 fg buspirone on column S/N 100:1
- Resolution: 240,000 (at m/z 200)
- Unit Size: Each