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Shimadzu Scientific Instruments Inc
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  5. Shimadzu iMScope - Model QT - Imaging ...

Shimadzu iMScope - Model QT -Imaging Mass Microscope

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The iMScope QT boasts not only fusion with morphology studies but also excellent speed, sensitivity, and spatial resolution, clearing the way to next-generation mass spectrometry imaging.

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Combined Analysis

Fusion of observations from an optical microscope with MS images (exclusive to Shimadzu)MS images can be obtained flexibly and matched to observation images, either the entire image area or detailed portions of it. Measurement Results for the Cerebellum with 5 μm Spatial Resolution 

  • Sample ：Whole mouse brain
  • Matrix ：9-AA
  • Measurement region ：662×595（393890pix）
  • Measurement time: ：around 2.2 hours
Measurement Results for Whole Brain Sections in Negative Mode
  • Sample:Whole mouse brain
  • Matrix ：9-AA
  • Measurement region: ：1126×624（702624pix）
  • Measurement time：around 6 hours
Quantification and Distribution
Obtain qualitative and quantitative information from LC-MS as well as position information from mass spectrometry imaging (MSI) with a single instrument.The combined system, which can perform LC-MS analysis in addition to MSI analysis, provides both distribution information and quantitative analysis.
Use as an MSI System

Sections of mouse tissue administered with chlorpromazine were measured with the iMScope QT. The distribution of unaltered chlorpromazine including differences in abundance could be visualized without the need for labeling.

Use as an LC-MS System

From the consecutive sections, the positions circled in the figure above were excised using laser micro dissection (LMD), and the extracted liquid was measured with the LCMS-9030. The results below show a quantitative analysis of the concentration of chlorpromazine in the extracted liquid, carried out with LabSolutions Insight™. In this way, concentration differences of the pharmaceutical agent in the tissue sections indicated by MSI could be confirmed from the quantitative results determined using LC-MS.

In addition, it is possible to estimate the molecular formula of an unknown compound using the LabSolutions Insight Explore™ composition estimation function. In this case, when the peak at m/z = 319.10 determined using MSI was analyzed using the composition estimation function, the molecular formula for the unaltered chlorpromazine substance (C17H19N2SCl) was indicated as the most likely with the highest score.