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Sino - Model Anti-EGFR-10001-MM01 -Mouse Monoclonal Antibody
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EGFR / ErbB / HER1 (rh EGFR / ErbB / HER1; Catalog #10001-H08H; Met 1-Ser 645; NP_005219). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
- Species reactivity Reacts with: Human
- Specificity
- Human EGFR
- No cross-reactivity in ELISA with
- Human EGFR/ErbB1
- Human ErbB2
- Human ErbB3
- Human ErbB4
- Human cell lysate (293 cell line)
- Immunogen Recombinant Human EGFR / ErbB / HER1 Protein (Catalog#10001-H08H)
- Source Monoclonal Mouse IgG2b Clone #3D2H11C5
- Purification Protein A
- Formulation 0.2 μm filtered solution in PBS
- Conjugate Unconjugated
- Form Liquid
- Shipping This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
- Storage This antibody can be stored at 2?-8? for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20? to -80?. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-EGFR Antibody, Mouse Monoclonal: Synonyms
Anti-ERBB Antibody; Anti-ERBB1 Antibody; Anti-HER1 Antibody; Anti-mENA Antibody; Anti-NISBD2 Antibody; Anti-PIG61 Antibody
EGFR Background Information
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.