Nirmidas - Model pGOLD -Slides Assay Platform Plasmonic Gold Film Technology
Plasmonic gold allows for a significant improvement in signal-to-noise ratio, surpassing other substrates and beads by up to 100 fold in sensitivity and dynamic range. Plasmonic gold (pGOLD™) substrates and beads are useful for fluorescence and Raman based cellular imaging and molecular assays.
Our pGOLD™ technology:
- suppresses or blocks background signals
- enables multi-color imaging
- can be compatible with standard cellular imaging, microarrays, and flow cytometric assay steps and equipment
pGOLD™, our innovative signal amplifying platform, originated from Stanford University and was published in Nature Communication and Nature Medicine. This technology is nano-engineered and is a signal enhancing near infra-red fluorescence detection platform. The high sensitivity of the pGOLD™ technology has already been displayed in novel assays for autoimmune diseases and infectious diseases.
PGOLD™ SLIDES PRODUCT
Plasmonic gold (pGOLD™) substrates and beads rely on nanoscience principles, such as nanogap enhanced excitation field strength and reduction in radiative lifetime of molecular excited states, to significantly increase the fluorescence emission of various fluorophores on the substrates.
The fluorescence enhancement is in the wavelength range of 500 – 900 nm for Si based detectors and persists to > 1000 nm for infrared detectors. Substrates are compatible with fluorophores such as Cy3, Cy5, IRDye680, and IRDye800 dyes in this wavelength range and give the highest enhancement in the near-infrared window. The substrate can also enhance the Raman scattering signals of molecules by orders of magnitude.
pGOLD™ slides are manufactured in compliance with ISO13485 regulations. The production follows rigorous work instructions and quality control procedures to ensure consistent performance and stability for use in research and development, and clinical tests in the near future.
- Protein (Cytokine/antibody/antigen) detection
- DNA/RNA detection
- cfDNA/CTC/exosomes analysis
- Cell/tissue imaging
- Multi-color imaging
- Liquid Biopsy
- Biomarker discovery
- Therapeutics screening assay
- Potential for IVD and clinical use