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MedChemExpress - Model 2'-Hydroxychalcone -1214-47-7

2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].

2′-Hydroxychalcone

MCE China：2′-Hydroxychalcone

Brand：MedChemExpress (MCE)

Cat. No.HY-W012349

CAS：1214-47-7

Purity：97.45%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp.

In Vitro：2′-Hydroxychalcone (10-90 μM; 12-72 h) suppresses cell viability in a dose-dependent manner, with IC50 values of 37.74 μM and 34.26 μM for the two breast cancer cell lines MCF-7 and CMT-1211, respectively[1]. 2′-Hydroxychalcone (10-30 μM; 24 h) promotes autophagy vesicle accumulation in breast cancer cells[1]. 2′-Hydroxychalcone (30 μM; 24 h) induces autophagy-dependent apoptosis in breast cancer cells, and increases cleavage of caspase-3 and PARP[1]. 2′-Hydroxychalcone (10-30 μM; 24 h) significantly reduces the expression of p-IκB and p-NF-κBp65, and elevates the levels of p-ERK and p-JNK[1]. 2′-Hydroxychalcone (30 μM; 12-24 h) increased the intracellular ROS levels and triggered endoplasmic reticulum stress (ERS) of breast cancer cells[1].

In Vivo：2'-Hydroxychalcone (20-60 mg/kg; ip; every 2 days; 3 weeks) could exhibit an antitumor effect in vivo without causing significant toxicity to essential organs[1].

References：

[1]. Xiao Wang, et al. 2'-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies. Nutrients. 2024 Feb 13;16(4):514. [Content Brief]

[2]. Kaila P Medina-Alarcón, et al. Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp. Future Microbiol. 2020 Jan:15:21-33. [Content Brief]

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MedChemExpress - Model 2'-Hydroxychalcone -1214-47-7

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2′-Hydroxychalcone