System-c - Single-use Device for Adherent Cell Cultures

CellScrew is a single-use device engineered for adherent cell cultures, offering a substantial growth area to volume ratio. It is constructed using plant-derived poly-lactic acid (PLA) synthesized through an additive manufacturing process. The device incorporates unique internal structures such as the Archimedes Screw and concentric cylinders, which produce a low-shear stress mixed environment conducive to cell growth and efficient nutrient and oxygen exchange. These features ensure optimal conditions for cell attachment and development. The surface, treated for enhanced cell adherence, supports extensive growth. Significantly, the design minimizes both manufacturing costs and environmental impact, boasting over a 90% reduction in CO2 emission compared to traditional multilayer flasks. CellScrew is adaptable from laboratory experiments to large-scale manufacturing setups, eliminating the need for additional process development during scaling. Its operation includes slow rotation for media circulation, coupled with ongoing mixing to foster ideal cell cultivation conditions.