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MedChemExpress - Model Luteinizing Hormone Releasing Hormone (LH-RH), sal -86073-88-3

Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

Luteinizing Hormone Releasing Hormone (LH-RH), salmon

MCE China：Luteinizing Hormone Releasing Hormone (LH-RH), salmon

Brand：MedChemExpress (MCE)

Cat. No.HY-P0243

CAS：86073-88-3

Synonyms：Salmon GnRH; Salmon gonadotropin-releasing hormone; sGnRH

Purity：99.69%

Storage：Sealed storage, away from moisture and light Powder -80°C 2 years -20°C 1 year *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

In Vitro：Luteinizing hormone-releasing hormone (LHRH) is the key hormone in the control of reproductive functions.LHRH acts as an antimitogenic factor through the activation of the Gi-cAMP intracellular signaling pathway. LHRH might act as an inhibitory factor on both cell proliferation and metastatic behavior in melanoma cells[1]. The hypothalamic decapeptide luteinizing hormone-releasing hormone (LHRH) plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn promote gonadal functions and regulate sex steroid secretion. The effects of LHRH are mediated by high-affinity G protein-coupled LHRH-receptor (LHRH-R) on pituitary gonadotropes. The responses to LHRH vary under different conditions and critically depend on the regimens of administration and doses delivered to gonadotrope cells[2].

Sequence：{Glp}-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH2

References：

[1]. Moretti RM, et al. Inhibitory activity of luteinizing hormone-releasing hormone on tumor growth and progression. Endocr Relat Cancer. 2003 Jun;10(2):161-7. [Content Brief]

[2]. Horvath JE, et al. Effects of long-term treatment with the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl and the LHRH antagonist Cetrorelix on the levels of pituitary LHRH receptors and their mRNA expression in rats. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15048-53. [Content Brief]

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MedChemExpress - Model Luteinizing Hormone Releasing Hormone (LH-RH), sal -86073-88-3

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Luteinizing Hormone Releasing Hormone (LH-RH), salmon