MedChemExpress - Model Procaspase-3/6 activator 1 -1100353-03-4
Procaspase-3/6 activator 1 (compound 1541) is a highly specific and robust activator of executioner procaspases-3 and -6, with EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. Procaspase-3/6 activator 1 does not activate procaspases-1 or -7[1].MCE products for research use only. We do not sell to patients.
Procaspase-3/6 activator 1
MCE China：Procaspase-3/6 activator 1
Brand：MedChemExpress (MCE)
Cat. No.HY-10131
CAS：1100353-03-4
Purity：98.97%
Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Procaspase-3/6 activator 1 (compound 1541) is a highly specific and robust activator of executioner procaspases-3 and -6, with EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. Procaspase-3/6 activator 1 does not activate procaspases-1 or -7.
In Vitro：Procaspase-3 at 100 nM was incubated with Procaspase-3/6 activator 1 (compound 1541) (100 nM to 100 μM). After a 4-hour incubation at 37°C, the samples were assayed for caspase activity by addition of Ac-DEVD-AFC. Low concentrations of 1541 induce activity of procaspase-3 with an EC50 of 2.4 μM, and, at high concentrations, inhibit with an IC50 of 34.0 μM[1]. Procaspase-3/6 activator 1 (compound 1541) exerts a similar inhibitory effect on active caspase-3 (IC50 = 35 μM), as seen for procaspase-3[1].
IC50 & Target：Procaspase-3 2.4 ± 0.2 μM (EC50) Procaspase-6 2.8 ± 0.3 μM (EC50)
Hot selling product：Degarelix | EC359 | Brentuximab | Veliparib | JG-2016 | 20-5,14-HEDGE | Sotatercept | Zibotentan | Salinomycin | Camptothecin
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References：
[1]. Wolan DW, et al. Small-molecule activators of a proenzyme. Science. 2009 Nov 6;326(5954):853-8. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。