MedChemExpress - Model Bevantolol hydrochloride -42864-78-8
Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist[1][2].MCE products for research use only. We do not sell to patients.
Bevantolol hydrochloride
MCE China：Bevantolol hydrochloride
Brand：MedChemExpress (MCE)
Cat. No.HY-121186
CAS：42864-78-8
Purity：98.98%
Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist.
In Vitro：Bevantolol hydrochloride has a pKi of 6.23 for β2-adrenergic receptor[1].
In Vivo：Bevantolol hydrochloride (200 mg/kg; PO by water; for 6 weeks) produces a significant decrease in the expression level of β1 adrenoceptor mRNA[2].
IC50 & Target：α adrenergic receptor β adrenergic receptor
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References：
[1]. M Takita, et al. Selectivity of Bevantolol Hydrochloride Towards Alpha- And Beta-Adrenoceptor Subtypes in Rat Cerebral Cortex. Jpn J Pharmacol. 1992 Feb;58(2):193-6. [Content Brief]
[2]. Takahiro Horinouchi, et al. Different Changes of Plasma Membrane Beta-Adrenoceptors in Rat Heart After Chronic Administration of Propranolol, Atenolol and Bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. [Content Brief]
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