Santa Cruz Biotechnology, Inc. - Tris base

Tris base is widely used as a biological buffer or as a component of buffer formulations such as TAE (sc-296645) and TBE (sc-296650) buffers. Tris base has a pKa of 8.06 and is very useful in the biology and biochemistry lab because tris base has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris base has been reported to interfere with the activity of a number of enzymes, therefore tris base should be used carefully when studying proteins. Tris base is also known as THAM, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, and Tris(hydroxymethyl)aminomethane.