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MedChemExpressModel 4,5-Dimethoxycanthin-6-one -18110-87-7

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4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].
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4,5-Dimethoxycanthin-6-one

MCE China:4,5-Dimethoxycanthin-6-one

Brand:MedChemExpress (MCE)

Cat. No.HY-N1882

CAS:18110-87-7

Purity:98.68%

Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae).

In Vitro:4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM[2].

IC50 & Target:CYP1A2 1.7 μM (IC50) CYP1A2 2.6 μM (Ki)

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References:

[1]. Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents

[2]. Miao X,et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51.  [Content Brief]

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