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Ziphius - Lipid Nano Particles Technology(LNP)
Lipid nanoparticle (LNP)-based delivery is a cutting-edge technology to carry nucleic acids into the cell cytoplasm of specifictarget organs. LNPs provide an extra layer of protection to RNA molecules from RNase mediated degradation. LNPs consists of a combination of various lipids with each having specific functions. Overall, the lipid bilayer surrounds an aqueous core, where the RNA is incorporated.
The in-house developed LNP library at Ziphius is specifically designed for saRNA delivery and ensures proper encapsulation, stability, and biodegradability of the LNP-saRNA complex. Furthermore, Ziphius is also focused on making LNPs for various administration routes for vaccination and supplementation therapies. The platform is being optimized to target specific organs and tissues, to minimize acute and chronic toxicity, and to acquire the most optimal prophylactic vaccination or gene supplementation effect.
LNP-mediated delivery of saRNA into the cells and induction of an immune response or gene supplementation is carried out as follows:
- Cellular uptake of the LNP by endocytosis and taken up by endosomes.
- A pH change in endosome causes the LNPs to change structure, releasing the saRNA in cytoplasm.
- The saRNA is amplified by its replication machinery and translated in targeted protein in cytosol.
- The proteins can induce a targeted immune response for vaccination or act as a protein supplementation therapy.