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InSphero AG
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  5. 3D InSight - 14 Day Hepatotoxicity ...

3D InSight - 14 Day Hepatotoxicity Testing

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Predict potential drug-induced liver injury (DILI) in vitro with advanced 3D liver microtissues. 3D InSight™ 14 Day Hepatotoxicity Testing assesses the effect of compounds on cellular viability in our standardized 3D InSight™ Human Liver Microtissues, developed from primary human hepatocytes in co-culture with Kupffer cells and liver endothelial cells (LECs). Cell viability dose-response curves are determined following a 14-day, repeat dose exposure to compounds.

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in vitro toxicology
in vitro
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  • Predict DILI with twice the sensitivity of standard 2D PHH assays without sacrificing specificity (1)
  • Test in our mechanistically relevant, extensively validated 3D liver model, developed using pooled multi-donor primary human hepatocytes (PHH) in co-culture with Kupffer cells and liver endothelial cells (1)
  • Customize your study with additional functional and mechanistic endpoints as needed

  • 7-point dose response curve
  • 14 day, repeat-dosing protocol
  • Cell viability endpoint
  • 3-4 week turnaround time