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Biomanufacturing Process & Quality Services
LumaCyte`s Radiance instrument enables real-time monitoring of biological production systems. In an at-line (periodic bioreactor sampling) configuration, Radiance can monitor mammalian, insect, yeast or other cells for production parameters. Many methods for biologics manufacturing use viruses and cell lines to produce the therapeutic or vaccine.
Radiance can quickly and cost effectively detect viral infection during these processes, making it invaluable for process optimization and scale-up. This broad applicability stems from the ability to rapidly detect viral infection or cellular changes in a variety of cell types. Changes in cellular morphology, biochemistry (compositional changes in the cytoplasm, for example), or development of viral inclusion bodies in infected cells give rise to measurable differences in cells. This capability gives Radiance the distinct advantage over other detection technologies of being useable in-line for real-time process monitoring.
Mammalian cells grown in a bioreactor connected directly to Radiance monitoring infectivity during the production of a vaccine.