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Developmental and Reproductive Toxicology Service

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We offer a broad scope and wide range of DART services: Fertility (male and/or female); Embryo-fetal development/prenatal developmental toxicity study; Prenatal and postnatal development, including maternal function; Combined 28-day/reproduction screening; One- and two-generation reproduction study; EOGRTS.

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Scope and range of services:

  • Studies
    • OECD 426: Developmental neurotoxicity study
    • EPA OPPTS 870.6300: Developmental neurotoxicity study
  • Evaluations
    • Clinical observations and bodyweight
    • Neuropathology (immersion or perfusion fixation)
    • Sexual maturation
    • Other developmental landmarks
    • Behavioral ontogeny
    • Motor activity
    • Motor and sensory function (auditory startle)
    • Learning and memory

Scope and range of services:

  • Customized study designs
    • Species selection and age for intended patient populations
    • Consideration of timing of dosing, exposure, monitoring, pharmacological/toxicological differences
  • Evaluations
    • Routine and target organ toxicological endpoints
    • Nervous system
    • Reproductive systems
    • Skeletal system (growth)
    • Neurobehavioral