Fermentation Broth Extraction Solvent Service

MKS Contribution: we used Synapse to conduct a full solvent selection by: 1) identifying and quantifying all important constraints; 2) eliminating all candidates that has substructures that could lead to chemical instability; 3) screening candidates for satisfactory solubility and volatility constraints; 4) examining commercial availability and cost of the final solvent candidates.

When we design an extraction solvent, the liquid-liquid equilibrium curve is of immediate importance. The equilibrium curve will show how the product will partition between the parent liquour and a candidate solvent. However, it is also important to examine volatility considerations, because the extraction solvent must be regenerated by distillation. Examining for the occurrence of azeotropes is of key importance in this step.