Embryologically, Human Pleural Mesothelial Cell Line originate from the mesoderm, and cells gradually differentiate from round or cuboidal cells to elongated cells lining the celomic cavity. However, they share many properties of epithelial cells, such as apical/basal polarity, basement membrane adhesion, junctional complexes, and surface microvilli. Their dual phenotypic features affect the function of these cells, determining how they respond to environmental changes.
