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MtoZ Biolabs - Model determination-of-peptide-structure -Peptide Structure Determination Service
Peptides are abundant in living organisms, actively participating in key biological processes such as hormone regulation, enzyme catalysis, and immune responses. Their spatial structure and functional features greatly influence their biological activity. Accurately determining peptide structures is essential for understanding peptide folding patterns, bioactivity, and structural features. It also informs drug development and bioengineering optimization. Peptide structure determination is valuable in biomedical research and drug development, providing insight into protein structure-function relationships, supporting drug design, and advancing vaccine research. Furthermore, it is critical in studying disease mechanisms, developing protein-based drugs, and refining biotechnology applications.
1. Sample Preparation
Extract and purify target peptides using high-performance liquid chromatography (HPLC) or other suitable techniques. Desalt and concentrate purified peptides to meet structural analysis requirements.
2. Sequence Analysis
(1) Select appropriate enzymes to digest peptide samples based on sequence characteristics, producing fragments for mass spectrometry analysis.
(2) Use HPLC to separate enzymatically cleaved peptides.
(3) Determine peptide fragments' amino acid composition and sequence via Edman degradation or tandem mass spectrometry (MS/MS), revealing the primary peptide structure.
3. Structural Analysis
Measure the peptide’s ultraviolet absorption by circular dichroism (CD), identifying their internal secondary structure elements such as α-helices and β-folds.
1. Revealing Protein Structure
Peptide structure determination identifies protein structures, including secondary, tertiary, and quaternary structures.
2. Studying Protein Function
Since protein structure closely correlates with function, peptide structure determination illuminates these relationships.
3. New Drug Development
By identifying drug-target protein interactions, peptide structure determination provides crucial insights for drug design.
4. Disease Diagnosis and Treatment
Peptide structure determination helps identify disease-specific biomarkers, enhancing early diagnosis and treatment efficacy.
In the technical report, MtoZ Biolabs will provide you with a detailed technical information, including:
1. Experimental Procedures
2. Relevant Mass Spectrometry Parameters
3. Peptide Structure Determination Detailed Information
4. Mass Spectrometry Images
5. Raw Data
MtoZ Biolabs is an integrate contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative multiplexed proteomics and metabolomics applications through the establishment of state-of-the-art mass spectrometry platforms, coupled with high-performance liquid chromatography technology. We are committed to developing efficient, and effective tools for addressing core bioinformatics problems. With a continuing focus on quality, MtoZ Biolabs is well equipped to help you with your needs in proteomics, metabolomics, bioinformatics, and biopharmaceutical research. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample.
Email: marketing@mtoz-biolabs.com