MtoZ Biolabs - Model protein-interaction-analysis -Protein Interaction Network Analysis Service
STRING is a database that records predicted and experimentally validated protein-protein interactions (PPIs) across multiple species, including direct physical interactions and indirect functional associations. By integrating the results of differential expression analysis and the interaction pairs recorded in the database, a differential expression protein interaction network is constructed. During the analysis, differentially expressed proteins are mapped to the STRING database to obtain information on their interaction relationships. As the STRING database includes experimental data, results from text mining of PubMed abstracts, and aggregated data from other databases, as well as predictions made using bioinformatics methods, we select interaction pairs with a combined score greater than 0.4 (Medium) from the search results and use appropriate bioinformatics analysis software to visualize the interaction results. The results are shown in the below:
Figure 1. Evidence of Differential Expressed Protein Interactions from Different Sources (Evidence)
Note: Circles (nodes) represent proteins; Different colors indicate different proteins, and the circles contain the three-dimensional structure of the proteins. Lines indicate the interactions between proteins. Thicker lines indicate stronger interaction relationships. Dark lines indicate relationships in the evidence view circle but no relationships in the actions diagram.
MtoZ Biolabs is an integrate contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative multiplexed proteomics and metabolomics applications through the establishment of state-of-the-art mass spectrometry platforms, coupled with high-performance liquid chromatography technology. We are committed to developing efficient, and effective tools for addressing core bioinformatics problems. With a continuing focus on quality, MtoZ Biolabs is well equipped to help you with your needs in proteomics, metabolomics, bioinformatics, and biopharmaceutical research. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample.
Email: marketing@mtoz-biolabs.com