MtoZ Biolabs - Model top-down-ptms-analysis -Top-Down PTMs Analysis Service
Top-down mass spectrometry (TDMS) is highly effective for comprehensive analysis of protein post-translational modifications (PTMs) because it evaluates intact proteins or peptides without requiring hydrolysis. This method is particularly valuable in the analysis of biopharmaceutical proteins, such as monoclonal antibodies and recombinant proteins, where it preserves many unstable modifications that are often lost during collision-induced dissociation (CID) cleavage in shotgun approaches.
Zhang, H. et al. Circ Cardiovasc Genet. 2011.
Employing techniques like electron capture dissociation (ECD) and electron transfer dissociation (ETD), TDMS excels at accurately measuring the masses of whole proteins or peptides, quantifying various forms of modified proteins, creating detailed modification maps with high coverage, identifying unanticipated PTMs, and sequencing multiple modifications. Despite its relative novelty and the technical challenges it faces in sample preparation and processing throughput, top-down proteomics offers distinct benefits that render it crucial for detailed PTMs characterization.
At MtoZ Biolabs, our team of skilled proteomics scientists and technicians leverages extensive experience in top-down proteomics to deliver superior PTMs characterization services.
MtoZ Biolabs is an integrate contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative multiplexed proteomics and metabolomics applications through the establishment of state-of-the-art mass spectrometry platforms, coupled with high-performance liquid chromatography technology. We are committed to developing efficient, and effective tools for addressing core bioinformatics problems. With a continuing focus on quality, MtoZ Biolabs is well equipped to help you with your needs in proteomics, metabolomics, bioinformatics, and biopharmaceutical research. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample.
Email: marketing@mtoz-biolabs.com