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Professional Assay Services (PAS)
Professional Assay Services (PAS) provides GCLP-compliant RNAscope, BaseScope™, and miRNAscope™ in situ hybridization (ISH) assay services to support clinical and pre-clinical studies for our academic and biopharma partners. We provide end-to-end solutions from sample procurement to ISH staining to image analysis and reporting. Researchers who partner with Professional Assay Services will receive access to the most specialized and technically experienced RNAscope services of any CRO, provided by an expert multi-disciplinary team that includes PhD scientists and MDs, who serve our clients as technical experts, image analysis specialists and board-certified pathologists, spanning a broad array of scientific disciplines. With direct access to the developers of the technology, the PAS team provides unparalleled expertise in Bio-Techne’s ISH platforms and delivers fast, high quality data designed to meet your study objectives and timelines.
Why Choose PAS as Your ISH Service Provider?
- A decade of experience as a service provider, delivering 15,000+ stained slides per year
- An established history of servicing 28 of the 30 global pharmaceutical companies as well as dozens of cell and gene therapy biotech companies
- Ph.D.level scientists and MD pathologists who are specialized experts and provide scientific consultation for study design and data interpretation
What We Offer: Tissue-Based Expression Analysis
- Target validation. Screen and validate candidate targets by assessing target expression levels in drug-treated versus naïve samples or disease vs normal tissues
- Biomarker assay development. Evaluate candidate biomarker expression and establish assay performance and dynamic range using bioanalytical method validation guidelines
- AAV biodistribution. Profile the spatial distribution of AAV vector together with genetically modified transgenes to assess biodistribution and safety
- CAR/TCR biodistribution and function. Visualize the biodistribution of CAR T or TCR T cells within the tumor microenvironment and assess functionality with co-detection of immune cell markers and/or markers of activation
- Safety/toxicology tissue screening. Single-molecule detection for high sensitivity screening of normal tissues for pre-clinical ADME and safety assessment
- CDx assay development. Partner with ACD to support the assay prototype development, proof of concept and validation steps of your RNAscope CDx assay