Cell Culture Company, LLC
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Purification and Downstream Processing Services
At Cell Culture Company, we have the capability and expertise to perform purification and downstream processing for your monoclonal antibody or recombinant protein product. Cell Culture Company can execute your existing purification process, or work with you to develop a robust purification process for your cell culture supernatant and protein.
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Protein Types
- Various Species of IgG and IgM Monoclonal Antibodies
- Antibody Fragments and Derivatives – Fab, F(ab)2, scFV, BiTE, sdAb, Bispecific Antibodies
- Recombinant Proteins – Fc-Fusion Proteins, Tagged Proteins (His, FLAG, GST, MBP, etc.)
Chromatography
- Affinity – Protein A/G/L, CaptureSelect, IMAC, Glutathione, etc.
- Mixed-mode – Capto™ adhere/MMC, CHT, etc.
- Ion Exchange
- Hydrophobic Interaction
- Size Exclusion
Technical Services
- Technology Transfer
- Process Development
- Non-GMP (RUO/Pre-Clinical) Manufacturing
- Process Evaluation and Validation
- GMP Manufacturing Support
Scale
- Analytical to preparative column chromatography
- Microgram to multi-gram quantities
Processing
- Clarification
- Polishing
- Viral Inactivation and Filtration
- Ultrafiltration/Diafiltration
- Sterile Filtration
- Formulation
Common Antibodies
- GK1.5
- 2.43
- MP6-XT22
- 2A6.9.9
- 9G4
- 1F11
Additional Services
- Deglycosylation
- Endotoxin Removal
- Conjugation/Labeling
- Enzymatic Cleavage
Outsourcing Support
- Viral Clearance Studies
- Impurity Analysis
- Formulation Studies
- Large Batch Final Fill