- Home
- Companies
- Invicro, LLC
- Services
- Radiochemistry Services
Radiochemistry Services
Our radiochemistry team has successfully radiolabeled over 300 biological agents, 500 small molecules and submitted 80 INDs for clinical use of novel radiotracers. This wide range of chemical entities has included CNS-penetrant small molecules, monoclonal antibodies, PSMA-targeted peptides, intrathecally administered molecules, virus and live cell labeling, and heart and blood targeting agents.
In addition to radiochemistry services, we also offer ligand design capabilities and medicinal chemistry support for optimization and synthesis of new ligands. This includes a in-house organic synthesis lab and partnered CROs for outsourcing DMPK analysis. In addition to in vitro screening, we also perform in silico virtual screening of existing compound libraries to aid in your ligand selection processes.
- Manufacturing for clinical use according to GMP, USP 823, and CFR part 212
- Deep expertise in automated synthesis module, including GE, Eckert and Zeigler, and ORA systems
- Wide range of chemotype handling, from amino acids/sugars to macromolecules and viruses
- Numerous purification methods including HPLC, spin-column and solid-phase extraction
- Ga-68 generator on site
- Siemens Cyclone cyclotrons for C-11 and F-18 production
- Rapid method transfers between Invicro sites
- Shipping of manufactured tracers to off-site scanning facilities
- Outsource tritiation of reagents
- HPLC methodology including RP, HYNIC, SE, IE and UPLC
- In-house development of bioactivity and immunoreactivity assays
- Full metabolite analysis (blood, urine, and brain) to support modeling needs
- Cell binding, tissue binding and cell internalization assay method development
- CMP panel/urine analysis for monitoring metabolic health
- UV/Vis spectrophotometer
- GC for residual solvent
- SDS-page electrophoresis
- Gamma counters for tissue analysis
- Dose calibrator and multi-channel analyzers
- Radio-TLC scanners