Reduced Representation Bisulfite Sequencing (RRBS) Service

Reduced Representation Bisulfite Sequencing (RRBS) is an enhanced bisulfite-based sequencing method utilized to detect up 7 – 8 million unique CpG sites, covering nearly all CpG islands, gene promoters, and most genetic regulatory elements, gene bodies, and repeated DNA sequences. RRBS is an NGS platform used to analyze the genome-wide methylation at base resolution detail by the use of a restriction enzyme and bisulfite treatment to focus on the areas in the genome that have a high CpG content. This is typically designed for researchers who are looking for cost effective ways to perform the sequencing instead of having Whole Genome Bisulfite Sequencing (WGBS) performed. RRBS is typically recommended for first time users with bisulfite sequencing based on the optimized price and data you would receive when performing this experiment.