Waters Corporation

MassLynx Mass Spectrometry Software

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Acquire, Analyze, Manage, and Share Mass Spectrometry Information - Waters' MassLynx Software improves your MS system with its intuitive interface, intelligent instrument control, and software features built around the focus of your analysis: the sample. With much of its development driven by input from our extensive user base, MassLynx has evolved into a powerful software package that delivers the versatility and flexibility you require. To assist with both data acquisition and the transformation of data into usable results, MassLynx Software offers easy-to-use Application Managers that allow you to focus the power of MS on your laboratory's specific tasks.

Sophisticated Mass Spectrometry Control
By placing the relevant sample information in one location, this 'sample centric' approach simplifies the interaction with your MS or MS/MS system, acquired data and processed results, thereby increasing the speed at which you can convert your samples into valuable knowledge.

The real power of MassLynx Software lies in its ability to intelligently control an entire Waters mass spectrometry system, from the sample and solvent management components to the mass spectrometer and auxiliary detectors. MassLynx Software can acquire nominal mass, exact mass, MS/MS and exact mass MS/MS data.

MassLynx Software provides sophisticated general purpose and specialized Application Managers that are tailored to provide data for specific types of MS analysis and information. QuanLynx™, included with MassLynx, provides automated quantification. OpenLynx™ Processing, also included with MassLynx, offers qualitative screening and identification. Mass-directed purification, deconvolution of complex chromatograms to determine all constituents, metabolite id, metabonomics and protein identification are available with these optional Application Managers.

Strictly regulated laboratory environments place significant demands on LC/MS and LC/MS/MS systems: to maximize performance while also maintaining the security of data. MassLynx Software features a 21 CFR Part 11 compatible security system built on the latest file encryption, audit log and secure archival/retrieval technology. The security system is flexible, allowing you to tailor and deploy security policies that meet the requirements of your laboratory.

The MassLynx™ Software user interface ensures direct access to frequently used functionality. The MassLynx toolbar, which is displayed alongside the Sample List, provides instant access to instrument status information, sample queue and Application Managers. A single mouse click switches between views of the queue and instrument status. Tabs select general or application-specific tools.

The ability to access basic sample information and system functionality through the MassLynx toolbar allows a novice user to begin operating the system with a minimal learning curve.

MassLynx Software’s control of Waters mass spectrometers, using integrated embedded PC technology (EPCAS™), places intelligence and real-time functionality inside every instrument. MassLynx Software provides the ability to collect nominal or exact mass MS and MS/MS data. MassLynx is fully compatible with Windows XP and Windows. Advanced control of Waters and third-party LC pumps, autosamplers, detectors and Agilent GC Systems enables flexible chromatographic configurations. Data Directed Analysis (DDA™) allows automatic switching from MS to MS/MS acquisition when a compound of interest is detected. MassLynx enables highly accurate and automated exact mass measurement using the internal reference standard from the LockSpray™ source (for time-of-flight systems). MassLynx fully supports a variety of ionization sources, including ESI, APcI, ESCi® Multi-Mode Ionization, IonSABRE™ APcI, Photoionization (PI), LockSpray, NanoLockSpray™, MUX-technology™, GC, direct probes and MALDI MS.

MassLynx Application Managers streamline application-specific data processing. Included with MassLynx Software are two powerful Application Managers: OpenLynx™ for qualitative analysis and QuanLynx™ for quantitative analysis.

The OpenLynx Application Manager performs peak detection on your LC/UV, LC/MS, LC/MS/MS or GC/MS data and then carries out specified higher order processing. Processing may be as simple as a subtracting a background spectrum or as sophisticated as predicting the elemental composition of analytes based on exact mass and isotope patterns. Typical uses for OpenLynx Processing include:

  • Confirmation of synthetic products
  • Estimation of purity and yield of synthetic reactions
  • Elemental composition predictions
  • Compound identification using user-created or commercial spectral libraries

The QuanLynx Application Manager provides automated quantification of LC/MS or LC/MS/MS data. QuanLynx quickly generates results from acquired data sets permitting accurate quantification and review of results. Peak integration with Waters’ advanced ApexTrack™ peak detection algorithm automates chromatographic peak detection and baseline determination (including tailing, skew, shoulders) and avoids manual optimisation of integration for individual peaks where chromatography is not ideal.

Processed results are presented in the QuanLynx browser. The interactive summary table presents information from the acquisition Sample List plus the related quantitation results. The display can be filtered to display all samples for an analyte or all analytes for a single sample. The chromatogram window permits manual optimization of integration. Results may be recalculated and saved in the portable browser file.

Data integrity is maintained with the QuanLynx audit log including the who, what, when and why of changes. Permission-based changes support GxP and other regulatory requirements. Electronic signature capability, implemented according to local Standard Operating Procedures, is available whenever necessary.

Configurable electronic and printed report formats permit output to paper and to files that may be transferred to other software applications (*.txt, *.CSV, *.XML, etc.). Direct export to LIMS is also available for immediate results transfer and distribution.

MassLynx Application Managers produce portable report files that enable you to share and review data without needing to have the full application installed. Convenient browser utilities are associated with most MassLynx Application Managers. The browser files may be stored in shared directories or sent to users by e-mail. As an example, users may review QuanLynx results, optimizing integration, confirm all sample results and sign-off the data set using only the QuanLynx browser, not the full MassLynx application.

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