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SentrySciences - Version ParticleSentry -Particle Image Analysis Software
ParticleSentry?? is a software product that brings artificial intelligence and particle imaging analysis technologies together in biopharmaceutical formulation development, scale-up and production. Our technology combines machine learning and computational statistics to identify protein aggregation and support biopharmaceutical characterization, enabling better understanding and control of your drug product. Our patent-pending technology creates "fingerprints" that quantitatively characterize protein drug production and protein aggregates under different stressors. These fingerprints are used to identify and resolve issues at every stage of product development and manufacture of large molecule protein therapeutics.
ParticleSentry?? is compatible with flow-imaging microscopy, backgrounded membrane imaging and microfluidic imaging platforms, and employs a convolutional neural network to perform particle image analysis and outlier subvisible particle detection. When used for biopharmaceutical characterization during formulation and development, the fingerprint of natural state drugs lays the foundation for heterogeneous particle analysis. Subvisible particle images taken from drug stressed states like those encountered during tangential flow filtration, mixing, freeze-thaw, pH and viral clearance, pump/filling, shaking and light induced stressors expand the utility of the fingerprint by enabling comparison of future outlier results and speed root-cause analysis. The fingerprint can also be valuable in analysis of container/closure, timed storage, forced degradation activities, and follows the drug into scale-up and production.