Waters Corporation

TargetLynx Application Manager

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Quantitative analytical labs are required to report the implications of environmental, human health, legal, and financial factors such as: Toxic residues in foodstuffs, Testing athletes for performance-enhancing drugs in sports, Safety tests in pharmaceutical development. The demand by regulatory authorities for assurance of confirmation in quantitative analysis is increasing. To ensure cost-effective compliance, Waters offers software that gives you confidence in your results and eliminates laborious, time-consuming and expensive manual checks.

The TargetLynx Application Manager, part of MassLynx Software , automates data acquisition, processing and reporting for quantitative results. It incorporates a range of confirmatory checks that identify samples that fall outside user-specified or regulatory thresholds.

TargetLynx includes all of the functionality of QuanLynx, the MassLynx Application Manager for high performance quantification. TargetLynx can be used with LC/MS(/MS) or GC/MS(/MS) data. This data can be selected ion monitoring (SIM), multiple reaction monitoring (MRM), or full scan/full spectrum. In the case of full scan/spectrum data, extracted ion chromatograms are used for quantification.

TargetLynx is able to rapidly identify and flag samples where:

  • Analytes are above a specified maximum reporting level (MRL)
  • Analyte confirmatory ion ratios are outside specified limits
  • One or more analyte signal-to-noise ratios are below a defined value
  • An analyte retention time or relative retention time is outside limits
  • An analyte concentration is below set LOD and LOQ thresholds
  • The standard deviation of response for QC standards exceeds a defined value
  • The blank response is too high
  • The coefficient of determination (r 2 ) of the calibration curve exceeds a defined value

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