Find out how Dotmatics can help with the challenges of these areas of biotechnology:

Analytical chemistry and Bioanalysis

Capturing and storing the quantitative results of analysis on small and macromolecules is essential for information flow through the discovery process.

Studies Notebook, Dotmatics electronic laboratory notebook for chemistry and biology provides a highly configurable form based solution for entry of experimental data. Microsoft Office documents can be stored and text indexed for more ad-hoc results.

Biotherapeutics

The number of biotherapeutic drugs in the market is increasing as more companies are looking to macromolecules for the next blockbuster drug molecule. This has created new challenges in biotechnology for data registration and management of biological entities.

Bioregister from Dotmatics for registering and managing biological entities through the drug discovery process offers a solution to tracking unique biological entities, managing data associated with their production including, expression, purification and characterization and can track sequence information.

Screening

Searching for active drug molecules is expensive and time consuming and using modern screening techniques can produce millions of chemical, genetic or pharmacological results. Managing the data associated with these experiments is fundamental to the success of a biotechnology company of any size.

Using Dotmatics Studies solution for assay management scientists can analyze the raw instrument data quickly and effectively and store this directly in the database. This data can then be fully queried and reported, including plots using Dotmatics Browser solution. This makes it simple to query and report biological screening results and chemical data in one place.

Vortex from Dotmatics is a powerful visualization tool for screening data that can process hits from your screening campaigns in an automated approach. Plate data can be visualized out-of-the-box and used to analyse activity and data quality. Chemical series can also be analyzed to give insights for future screening projects.

Small Molecule Drug Discovery

The small molecule discovery industry is very competitive with many companies competing to discover drugs to act on the same target. It is crucial that biotechnology groups focusing on chemical molecules effectively manage their chemistry and biology data. Chemical libraries can reach in excess of million compounds along with associated biological screening results with each molecule. Storing data in Excel and SD files soon becomes unmanageable.

Browser from Dotmatics provides a project centric query and reporting solution that brings together all chemistry and biological data from a single or multiple disparate databases. It can also bring together data from third party database solutions to create a union of all discovery data.

Register from Dotmatics allows chemistry groups to create a corporate registration database. Scientists can perform single compound registration or a collection of molecules through an SD files registration. Register easily manages salt and batch information as well as any other associated Meta data.

Studies from Dotmatics allow small molecule focused biology groups to analyze plate or non plate based assays. Many of the typical analysis types are included out-of-the-box including IC50, EC50 and %inh. Scientists can also configure their own defined equations for analysis.

Vortex from Dotmatics allows small molecule discovery groups to visualize chemistry and biology data to perform structure activity relationship analysis. An array of plots and tools allow scientists to find trends, activity and outliers in data with chemical intelligence.

Dotmatics - Vortex