BRAVE Analytics products

BRAVE - Real-Time Nanoparticle Analyzer

BRAVE B-Curious is an advanced nanotechnology device designed for continuous, real-time characterization of nanoparticles. Utilizing the innovative OptoFluidic Force Induction (OF2i®) method, it surpasses traditional techniques like Dynamic Light Scattering (DLS), Nanoparticle Tracking Analysis (NTA), and Laser Diffraction by providing detailed insights into all particle populations within a sample. The device can measure up to 1000 particles per minute with single-particle sensitivity, offering representative and statistically relevant results. Its applications range from medical research on vaccines and drug delivery to laboratory analysis of complex systems, including lipid-injectable emulsions and water samples. The platform supports various modules for concentration determination, time-resolved sizing, and Raman spectroscopy, providing flexibility for specialized research needs. Additionally, it includes an automated self-cleaning cycle and can handle detection ranges from 50 nm to 50 µm, depending on sample conditions. BRAVE B-Curious enables researchers to monitor dynamic processes such as aggregation, crystallization, and dissolution in real time, offering a comprehensive tool for groundbreaking discoveries in nanoparticle behavior.

BRAVE - Real-time Online Nanoparticle Sensor

BRAVE B-Continuous is a pioneering PAT sensor designed for real-time online characterization of nanoparticles, specifically tailored to monitor essential parameters like particle size, number-based particle size distributions, and particle concentration during production. This sensor is capable of measuring a range of particle sizes from 50 nm to 5 µm, depending on the sample, and can detect ultra-low concentrations and aggregates. By providing continuous and accurate measurement data, BRAVE B-Continuous enables production processes to be optimized and adapted in real time. The sensor integrates seamlessly into production plants, delivering immediate data visibility across the network, which ensures precise monitoring and control without relying on lab analysis. The technology utilizes OptoFluidic Force Induction (OF2i®), an innovative method that moves beyond the limitations of conventional measures like Dynamic Light Scattering, to offer statistically significant results by analyzing up to 3000 particles per minute. Ideal for industries such as pharmaceuticals, cosmetics, and biotechnology, BRAVE B-Continuous supports real-time release testing, predictive maintenance, and stringent quality control measures for ultra-pure water and water for injections, making it a game-changer in the realm of nanoparticle management.

BRAVE - Continuous In-Flow Raman Particle Analyzer

The BRAVE B-Elementary is a cutting-edge Raman analysis device designed to streamline particle analysis by reducing the need for extensive sample preparation. This benchtop module allows for continuous in-flow Raman spectroscopy, enabling real-time detection and identification of particles such as substances, phases, and polymorphs. Capable of analyzing up to 60 particles per minute with single-particle precision, it provides statistically relevant results for applications like non-target screening and contamination detection. The B-Elementary's user-friendly design ensures minimal interaction and automated self-cleaning, making it accessible even for non-experts. With the ability to handle particle sizes ranging from 500 nm to 50 µm, this device is ideal for high-throughput environments. It can measure directly in sample flow, offering accurate particle size distribution and concentration. Future integrations aim to include it in production processes as a PAT sensor, enhancing its utility further. Researchers and technicians can benefit from its robust capabilities in fields like groundwater analysis, medicine, and waste water treatment.

Particle Analytics

BRAVE - OptoFluidic Force Induction for Particle Measurement in Research and Production

OptoFluidic Force Induction (OF2i®) is a patented technology designed for advanced nanoparticle characterization. Unlike conventional methods such as Dynamic Light Scattering (DLS) and Laser Diffraction, OF2i® enables continuous, real-time measurement of particle data, offering statistically significant insights into the entire particle population. Utilizing a donut-shaped vortex laser, it manipulates particles within a liquid sample, providing detailed analysis of particle size, distribution, and concentration. This method is applicable in diverse industries including pharmaceuticals, biotech, cosmetics, and environmental sciences. OF2i® offers products like BRAVE B-Continuous, an online PAT sensor for real-time process monitoring, and BRAVE B-Curious, a benchtop device for lab applications. The technology also integrates with Raman spectroscopy for detailed chemical analysis. By accelerating particles and minimizing Brownian motion effects, OF2i® ensures precise, representative measurement results, enhancing both research and production processes.

BRAVE - Analysis for Particle Characterization

BRAVE Analytics has developed a cutting-edge method for particle characterization by combining OptoFluidic Force Induction (OF2i) and Raman spectroscopy, inspired by Arthur Ashkin's optical tweezers. The technique uses light's ability to manipulate and trap particles, facilitating the measurement of particle size, concentration, and chemical composition in a continuous flow system. The BRAVE B-Elementary module features an innovative setup that slows down or stops particles momentarily to read their Raman spectra, achieving high-throughput analysis of up to 60 particles per minute. This user-friendly system requires minimal sample preparation and can process a wide range of particle sizes from approximately 500 nm to 5 µm. It can be enriched by integrating inductively coupled plasma-time-of-flight mass spectrometry (ICP-ToF-MS) for complementary analysis, delivering highly sensitive measurements even at ultra-low particle concentrations. Potential applications span from nanotoxicology and quality control in pharmaceuticals to environmental science, enabling detailed, accurate particle characterization.