Cerno Bioscience software

Adding to the legacy established in previous versions, MassWorks 6.0 is still the easy-to-use post acquisition software package that utilizes Cerno’s patented TrueCal™ technology to achieve high mass accuracy and high Spectral Accuracy and enable elemental composition determination on conventional mass spectrometers of unit mass resolution using the patented CLIPS formula search.  MassWorks sCLIPS and BestScan sCLIPS now also provide high spectral accuracy through exact line-shape calibration without the need for standards. MassWorks integrates the powerful TrueCal calibration technology to obtain up to 100X improvement in mass accuracy on unit resolution systems and up to 99.9% spectral accuracy on both high and unit resolution systems in a fast and versatile MS application software package. By mass accuracy with Spectral Accuracy, Cerno methodologies can provide significant improvements to all types of MS data, both high and low resolution.

NIST Library Support: Directly call NIST Search to perform a search on the current MS within Massworks with an accurate mass filter set to improve search confidence and quality. Directly perform a normal integer mass NIST search on the current MS within Massworks. Directly look up a formula from a MassWorks CLIPS search and find the library spectra and properties.

GC/ID is a fully automated data processing software that provides dramatic improvements for GC/MS qualitative analysis. By incorporating Cerno’s proven TrueCal™ calibration technology for accurate mass formula ID along with conventional library search, a significant improvement in compound ID certainty is achieved on single quad GC/MS systems. GC/ID also provides, for the first time, an entirely automated method of quantitatively utilizing the NIST, Wiley or user generated retention index values to provide yet a third orthogonal metric for compound ID. Finally, a powerful new approach is used to identify and deconvolve mixtures and the background of co-eluting peaks to minimize the mis-identification of compounds in complex samples.

MassWorks Rx is the prescription for improving your analytical results, increasing your productivity, reducing your costs,  and saving you time.  The Rx platform brings work flow automation and ease of configuration to an entirely new level.  Unlike most vendor software, Rx is vendor agnostic.  Rx transparently reads the native vendor data file format using Direct Read technology meaning that incorporating different vendor instruments into your workflow doesn’t mean starting all over again customizing the software.  Rx makes available MassWorks award winning, patented calibration technology to enable formula ID and mixture analysis on unit resolution instruments while improving formula ID on high resolution instruments.  Both small and large molecule analysis including accurate analysis of multiple charge state ions and degradation products can be performed as no other software can.

In conventional sCLIPS, typically the averaged MS across a chromatographic peak is used to correct the instrument line-shape and enable exact isotope modeling for Spectral Accuracy evaluation of various possible elemental compositions. With ultra-high resolution MS at ≥ 240,000 resolving power, the observed fine isotopes can vary systematically from scan to scan, depending on the ion population and the associated space charge effects. Best Scan sCLIPS goes beyond the conventional sCLIPS to evaluate the attainable Spectral Accuracy for each and every scan while searching for possible elemental compositions. The scan with the best Spectral Accuracy (oftentimes not at the chromatographic peak apex) will be selected and utilized for accurate elemental composition determination.